Research Article
Response Rates in a COVID-19 Seroepidemiological Survey in Nigeria: Variations by State, Age Group, and Urban-Rural Settings
Kazeem Adewale Osuolale*,
Adewale Kayode Ojogbede,
Adesola Zaidat Musa,
Oluwagbemiga Olanrewaju Aina,
Tajudeen Akanji Bamidele,
Olufemi Samuel Amoo,
Azuka Patrick Okwuraiwe,
Toyosi Raheem,
Nwachukwu William,
Chinwe Ochu,
Chima Ihemeje,
Ehichioya Ofeimun,
Abdul-rahaman Ahmad,
Abideen Salako,
David Oladele,
Fehintola Ige,
Ifeoma Idigbe,
Fatimah Anwoju,
Aigbe Ohihoin,
Adedeji Abimbola Modupe,
Joseph Shaibu,
Basit Baruwa,
Hussein Abdur-Razzaq,
Bisola Adebayo,
Richard Ikwuogu,
Christian Tetsola,
Gloria Patrick-Ferife,
Nathaniel Enamuotor,
Mildred Okowa,
Cornelius Ohonsi,
Magdalene Egede,
Mustapha Imam,
Muhammad Bashir Bello,
Muhammad Shuaibu Gobir,
Kikelomo Ololade Wright,
Oliver Ezechi,
Ehimario Igumbor,
Babatunde Lawal Salako,
Rosemary Audu
Issue:
Volume 13, Issue 1, February 2025
Pages:
1-11
Received:
8 November 2024
Accepted:
23 December 2024
Published:
9 January 2025
DOI:
10.11648/j.sjph.20251301.11
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Abstract: The COVID-19 pandemic has presented substantial global challenges, necessitating a deep understanding of infection dynamics across diverse populations. Seroepidemiological studies offer valuable insights into these dynamics but depend heavily on obtaining representative samples. This study aimed to assess participant response rates across different age groups and residence settings in Nigeria, focusing on three distinct locations: Lagos, Delta, and Sokoto States. The study utilized a probability sampling procedure, employing a two-stage cluster sampling method to select Enumeration Areas (EAs) and then households with equal probability. Data from the sero-epidemiological survey served as secondary data for analyzing response rates. The American Association for Public Opinion Research (AAPOR) Response Rate 4 (RR4) method was applied. Response rates were calculated, and analyses stratified by age and residence were conducted to examine survey response patterns. In Lagos State, response rates varied significantly across age groups and residence settings. Children aged <2 years had a response rate of 87.9%, but a lower survey response rate of 54.3%. The 2-9 years age group had a high response rate of 97.4% with a survey response rate of 75.5%. Adolescents (10-17 years) showed a response rate of 99.3% and a survey response rate of 83.5%. Adults aged 18-64 years had a response rate of 99.2% and a survey response rate of 86.8%. The 65+ years age group showed a response rate of 96.3% and a survey response rate of 85.9%. Urban areas had a higher response rate (99.1%) compared to rural areas (95.2%), with corresponding survey response rates of 85.5% and 73.1%, respectively. Sokoto State presented lower response rates, particularly among children aged <2 years (4.3%) and the elderly (65+ years) at 19.8%. Urban areas in Sokoto had significant challenges, with an overall response rate of 35.9% and a survey response rate of 4.1%. In contrast, Delta State showed more consistent results, with response rates of 93.2% overall and a survey response rate of 81.8%. The study highlights variations in response and survey response rates across different age groups and residence settings in Lagos, Delta and Sokoto States. These findings underscore the importance of considering demographic and geographic factors when interpreting seroepidemiological data.
Abstract: The COVID-19 pandemic has presented substantial global challenges, necessitating a deep understanding of infection dynamics across diverse populations. Seroepidemiological studies offer valuable insights into these dynamics but depend heavily on obtaining representative samples. This study aimed to assess participant response rates across different...
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Research Article
Uncommon Life-threatening Complication of Anti Tuberculosis Treatment
Dushantha Madegedara*,
Dhananjaya Ranathunga,
Dilky Hirushika Madegedara Rathnayake,
Damith Nissanka
Issue:
Volume 13, Issue 1, February 2025
Pages:
12-16
Received:
5 December 2024
Accepted:
16 December 2024
Published:
14 January 2025
DOI:
10.11648/j.sjph.20251301.12
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Views:
Abstract: This case report details the occurrence of adrenal insufficiency in a 46-year-old male undergoing anti-tuberculosis (TB) treatment. The patient developed clinical symptoms indicative of adrenal insufficiency on the fourth day following the initiation of anti-Tuberculosis treatment which consisted of rifampicin, a key component of the TB treatment regimen. Initial symptoms at fourth day of treatment included postural dizziness, fatigue, nausea, and abdominal pain. His biochemical investigations revealed hypoglycemia, hyperkalemia, mild metabolic acidosis, and a disproportionately low random cortisol level during the acute presentation. A diagnosis of rifampicin-induced adrenal insufficiency was strongly suspected, supported by clinical presentation and the temporal relationship to therapy initiation. The patient was subsequently transferred to the intensive care unit and his condition improved only after initiating, administering of hydrocortisone and discontinuing rifampicin therapy. Following stabilization, an alternative anti-TB regimen excluding rifampicin was introduced. The patient showed gradual clinical improvement with hydrocortisone therapy and continued TB treatment. The report discusses clinical presentation, diagnostic evaluation, management, and the importance of recognizing this potential life-threatening adverse effect providing insight into the critical need for increased awareness and early recognition of adrenal insufficiency as a rare but potentially life-threatening complication of anti-tuberculosis therapy, extending the importance to guiding clinical vigilance and treatment protocols. This case serves an important reference and supports the routine monitoring of adrenal function during rifampicin therapy to guide future clinical practice.
Abstract: This case report details the occurrence of adrenal insufficiency in a 46-year-old male undergoing anti-tuberculosis (TB) treatment. The patient developed clinical symptoms indicative of adrenal insufficiency on the fourth day following the initiation of anti-Tuberculosis treatment which consisted of rifampicin, a key component of the TB treatment r...
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