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Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease

Received: 5 December 2017     Published: 6 December 2017
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Abstract

In recent years, with the improvement of detection technology and medical level, the incidence of hypothyroidism, subclinical hypothyroidism and coronary heart disease was increasing year by year and patients were often associated with significant reduction of high-density lipoprotein cholesterol, increase of total cholesterol and Homocysteine and so on. But it was not clear whether there was a similar change occurs in patients with hypothyroidism complicated with coronary heart disease. The authors chose hospital patients, who were divided into a group of hypothyroidism complicated with coronary heart disease (merging group), a group of hypothyroidism, subclinical hypothyroidism and control group, with 60 cases in each group, to measure the blood lipid and Homocysteine, calculate blood lipid ratio and make analysis. As a result, the authors found that patients with hypothyroidism and merging group serum high-density lipoprotein cholesterol decreased. The levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, total cholesterol / high-density lipoprotein cholesterol, triglyceride / high-density lipoprotein cholesterol, low-density lipoprotein cholesterol / high-density lipoprotein cholesterol, lipid profile, non-high-density lipoprotein cholesterol and Homocysteine were significantly higher than the control group. And the group of patients with hypothyroidism complicated with coronary heart disease was higher than the hypothyroidism group. It came to the conclusion that dynamic monitoring of blood lipid and its ratio and the change of Homocysteine were important for clinical value in transforming subclinical hypothyroidism into hypothyroidism and predicting patients with hypothyroidism complicated with coronary heart disease.

Published in Science Journal of Public Health (Volume 5, Issue 6)
DOI 10.11648/j.sjph.20170506.20
Page(s) 469-473
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Hypothyroidism, Subclinical Hypothyroidism, Hypothyroidism Complicated with Coronary Heart Disease, Blood Lipid Ratio, Homocysteine

References
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[3] Lioudaki E, Mavroeidi NG, Mikhailidis DP, et al. Subclinical hypothyroidism and vascular risk:an update. Hormones (Athens), 2013, vol. 12, pp.495-506.
[4] Kamasaki H, Takeuchi T, Mikami T, et al. A case of graves’ disease diagnosed in the course of bilateral carotid artery stenoses (moyamoya disease );a case report and review of the literature. Clin Pediatr Endocrinol, 2013, vol. 22, pp. 39-44.
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[11] Toruner F, Altinova AE, Karakoc A, et al. Risk factorsfor cardiovascu1ar disease in patients with subclinical hypothyroidism. Adv Ther, 2008, vol. 25, pp. 430-437.
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[13] Liu CH, Xiao JX. To investigate the correlation between subclinical hypothyroidism and coronary heart disease. Prac Clin J Inte Tradi Chin Wes Med, 2016, vol. 16, pp.40-41.
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[17] Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, et al. The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. American Journal of Clinical and Experimental Medicine, 2017, vol. 5, pp. 108-114
[18] Wu ZR, Zhang LR, Pan YQ et al. Changes and clinical significance of serum homocysteine and lipids in Patients with primary hypothyroidism and hyperthyroid. Prog Mod Bio, 2009, vol. 22, pp. 4276-4278.
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  • APA Style

    Yuzhi Liu, Zhenjiang Hou, Jingyu Zhang, Jianzhang Hou, Hongsheng Wang. (2017). Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease. Science Journal of Public Health, 5(6), 469-473. https://doi.org/10.11648/j.sjph.20170506.20

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    ACS Style

    Yuzhi Liu; Zhenjiang Hou; Jingyu Zhang; Jianzhang Hou; Hongsheng Wang. Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease. Sci. J. Public Health 2017, 5(6), 469-473. doi: 10.11648/j.sjph.20170506.20

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    AMA Style

    Yuzhi Liu, Zhenjiang Hou, Jingyu Zhang, Jianzhang Hou, Hongsheng Wang. Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease. Sci J Public Health. 2017;5(6):469-473. doi: 10.11648/j.sjph.20170506.20

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  • @article{10.11648/j.sjph.20170506.20,
      author = {Yuzhi Liu and Zhenjiang Hou and Jingyu Zhang and Jianzhang Hou and Hongsheng Wang},
      title = {Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease},
      journal = {Science Journal of Public Health},
      volume = {5},
      number = {6},
      pages = {469-473},
      doi = {10.11648/j.sjph.20170506.20},
      url = {https://doi.org/10.11648/j.sjph.20170506.20},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20170506.20},
      abstract = {In recent years, with the improvement of detection technology and medical level, the incidence of hypothyroidism, subclinical hypothyroidism and coronary heart disease was increasing year by year and patients were often associated with significant reduction of high-density lipoprotein cholesterol, increase of total cholesterol and Homocysteine and so on. But it was not clear whether there was a similar change occurs in patients with hypothyroidism complicated with coronary heart disease. The authors chose hospital patients, who were divided into a group of hypothyroidism complicated with coronary heart disease (merging group), a group of hypothyroidism, subclinical hypothyroidism and control group, with 60 cases in each group, to measure the blood lipid and Homocysteine, calculate blood lipid ratio and make analysis. As a result, the authors found that patients with hypothyroidism and merging group serum high-density lipoprotein cholesterol decreased. The levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, total cholesterol / high-density lipoprotein cholesterol, triglyceride / high-density lipoprotein cholesterol, low-density lipoprotein cholesterol / high-density lipoprotein cholesterol, lipid profile, non-high-density lipoprotein cholesterol and Homocysteine were significantly higher than the control group. And the group of patients with hypothyroidism complicated with coronary heart disease was higher than the hypothyroidism group. It came to the conclusion that dynamic monitoring of blood lipid and its ratio and the change of Homocysteine were important for clinical value in transforming subclinical hypothyroidism into hypothyroidism and predicting patients with hypothyroidism complicated with coronary heart disease.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease
    AU  - Yuzhi Liu
    AU  - Zhenjiang Hou
    AU  - Jingyu Zhang
    AU  - Jianzhang Hou
    AU  - Hongsheng Wang
    Y1  - 2017/12/06
    PY  - 2017
    N1  - https://doi.org/10.11648/j.sjph.20170506.20
    DO  - 10.11648/j.sjph.20170506.20
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 469
    EP  - 473
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20170506.20
    AB  - In recent years, with the improvement of detection technology and medical level, the incidence of hypothyroidism, subclinical hypothyroidism and coronary heart disease was increasing year by year and patients were often associated with significant reduction of high-density lipoprotein cholesterol, increase of total cholesterol and Homocysteine and so on. But it was not clear whether there was a similar change occurs in patients with hypothyroidism complicated with coronary heart disease. The authors chose hospital patients, who were divided into a group of hypothyroidism complicated with coronary heart disease (merging group), a group of hypothyroidism, subclinical hypothyroidism and control group, with 60 cases in each group, to measure the blood lipid and Homocysteine, calculate blood lipid ratio and make analysis. As a result, the authors found that patients with hypothyroidism and merging group serum high-density lipoprotein cholesterol decreased. The levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, total cholesterol / high-density lipoprotein cholesterol, triglyceride / high-density lipoprotein cholesterol, low-density lipoprotein cholesterol / high-density lipoprotein cholesterol, lipid profile, non-high-density lipoprotein cholesterol and Homocysteine were significantly higher than the control group. And the group of patients with hypothyroidism complicated with coronary heart disease was higher than the hypothyroidism group. It came to the conclusion that dynamic monitoring of blood lipid and its ratio and the change of Homocysteine were important for clinical value in transforming subclinical hypothyroidism into hypothyroidism and predicting patients with hypothyroidism complicated with coronary heart disease.
    VL  - 5
    IS  - 6
    ER  - 

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Author Information
  • Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China

  • Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China

  • Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

  • Department of Surgery, Cangzhou People's Hospital, Cangzhou Medical College, Cangzhou, China

  • Diabetes Department of Endocrinology, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

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