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Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism

Received: 23 October 2020     Published: 27 November 2020
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Abstract

Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.

Published in Science Journal of Public Health (Volume 8, Issue 6)
DOI 10.11648/j.sjph.20200806.14
Page(s) 177-180
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Hyperthyroidism, IL-2, IL-6, IL-8, ET

References
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Cite This Article
  • APA Style

    Li Hongyan, Zhang Jingyu, Xu Qian, Wang Cuicui, Cao Tingting, et al. (2020). Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Science Journal of Public Health, 8(6), 177-180. https://doi.org/10.11648/j.sjph.20200806.14

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    ACS Style

    Li Hongyan; Zhang Jingyu; Xu Qian; Wang Cuicui; Cao Tingting, et al. Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Sci. J. Public Health 2020, 8(6), 177-180. doi: 10.11648/j.sjph.20200806.14

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    AMA Style

    Li Hongyan, Zhang Jingyu, Xu Qian, Wang Cuicui, Cao Tingting, et al. Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Sci J Public Health. 2020;8(6):177-180. doi: 10.11648/j.sjph.20200806.14

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  • @article{10.11648/j.sjph.20200806.14,
      author = {Li Hongyan and Zhang Jingyu and Xu Qian and Wang Cuicui and Cao Tingting and Hou Zhenjiang},
      title = {Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism},
      journal = {Science Journal of Public Health},
      volume = {8},
      number = {6},
      pages = {177-180},
      doi = {10.11648/j.sjph.20200806.14},
      url = {https://doi.org/10.11648/j.sjph.20200806.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200806.14},
      abstract = {Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism
    AU  - Li Hongyan
    AU  - Zhang Jingyu
    AU  - Xu Qian
    AU  - Wang Cuicui
    AU  - Cao Tingting
    AU  - Hou Zhenjiang
    Y1  - 2020/11/27
    PY  - 2020
    N1  - https://doi.org/10.11648/j.sjph.20200806.14
    DO  - 10.11648/j.sjph.20200806.14
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 177
    EP  - 180
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20200806.14
    AB  - Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.
    VL  - 8
    IS  - 6
    ER  - 

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Author Information
  • Department of Medical Technology of Cangzhou Medical College, Cangzhou, China

  • Department of Laboratory Diagnosis, Cangzhou Integrated of Traditional Chinese and Western Medicine Hospital of Hebei Province, Cangzhou, China

  • Department of Medical Technology of Cangzhou Medical College, Cangzhou, China

  • Department of Medical Technology of Cangzhou Medical College, Cangzhou, China

  • Department of Medical Technology of Cangzhou Medical College, Cangzhou, China

  • Cangzhou Thyroid Disease Engineering Research Center, Cangzhou, China

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