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Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism

Received: 22 July 2019     Published: 27 September 2019
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Abstract

Objective: This paper is to explore the relationship between IL-2, IL-6, IL-8 and the development of hyperthyroidism and subclinical hyperthyroidism. Methods The serum levels of IL-2, IL-6 and IL-8 were determined in 251 cases of hyperthyroidism, 242 cases of subclinical hyperthyroidism and 130 cases of normal control. Results The level of IL-2 in hyperthyroidism group was significantly lower than that in the control group (P<0.01), and the levels of IL-6 and IL-8 were significantly higher than those in the control group (P<0.01); The level of IL-2 in subclinical hyperthyroidism group was lower than that in the control group (P<0.05), and the levels of IL-6 and IL-8 were higher than those in the control group (P<0.05). The level of IL-2 in hyperthyroidism group was lower than that in subclinical hyperthyroidism group, and the level of IL-6 and IL-8 were higher than those in subclinical hyperthyroidism group. The two groups of IL-2 were negatively correlated with serum FT3, FT 4, TT3, and TT4, and IL-6 and IL-8 were positively correlated with serum FT3, FT 4, TT3, and TT4. Conclusions IL-2, IL-6, and IL-8 all participated in the development process of hyperthyroidism and subclinical hypothyroidism, which contributed to the early discovery of subclinical hyperthyroidism.

Published in Science Journal of Public Health (Volume 7, Issue 5)
DOI 10.11648/j.sjph.20190705.14
Page(s) 159-162
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Hypothyroidism, Subclinical Hypothyroidism, IL-2, IL-6, IL-8

References
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[13] Wang Xiaoying, Gaolin, Liao Xin. et al. Relevance study between serum levels of Visfatin, IL-6 and TNF-alpha and thyroid function in patients with Graves' disease [J]. Guizhou Medical Journal, 2018, 42 (02: 162-163).
[14] Shen J, Li Z, Li W, et a1. Thl, Th2, and Thl7 cytokine in—volvement in thyroid associated ophthalmopathy [J]. DisMarkers, 2015, 10 (7): 638-643.
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  • APA Style

    Li Hongyan, Zhang Chunhui, Wang Hongsheng, Xu Qian. (2019). Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism. Science Journal of Public Health, 7(5), 159-162. https://doi.org/10.11648/j.sjph.20190705.14

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    ACS Style

    Li Hongyan; Zhang Chunhui; Wang Hongsheng; Xu Qian. Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism. Sci. J. Public Health 2019, 7(5), 159-162. doi: 10.11648/j.sjph.20190705.14

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    AMA Style

    Li Hongyan, Zhang Chunhui, Wang Hongsheng, Xu Qian. Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism. Sci J Public Health. 2019;7(5):159-162. doi: 10.11648/j.sjph.20190705.14

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  • @article{10.11648/j.sjph.20190705.14,
      author = {Li Hongyan and Zhang Chunhui and Wang Hongsheng and Xu Qian},
      title = {Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism},
      journal = {Science Journal of Public Health},
      volume = {7},
      number = {5},
      pages = {159-162},
      doi = {10.11648/j.sjph.20190705.14},
      url = {https://doi.org/10.11648/j.sjph.20190705.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20190705.14},
      abstract = {Objective: This paper is to explore the relationship between IL-2, IL-6, IL-8 and the development of hyperthyroidism and subclinical hyperthyroidism. Methods The serum levels of IL-2, IL-6 and IL-8 were determined in 251 cases of hyperthyroidism, 242 cases of subclinical hyperthyroidism and 130 cases of normal control. Results The level of IL-2 in hyperthyroidism group was significantly lower than that in the control group (P<0.01), and the levels of IL-6 and IL-8 were significantly higher than those in the control group (P<0.01); The level of IL-2 in subclinical hyperthyroidism group was lower than that in the control group (P<0.05), and the levels of IL-6 and IL-8 were higher than those in the control group (P<0.05). The level of IL-2 in hyperthyroidism group was lower than that in subclinical hyperthyroidism group, and the level of IL-6 and IL-8 were higher than those in subclinical hyperthyroidism group. The two groups of IL-2 were negatively correlated with serum FT3, FT 4, TT3, and TT4, and IL-6 and IL-8 were positively correlated with serum FT3, FT 4, TT3, and TT4. Conclusions IL-2, IL-6, and IL-8 all participated in the development process of hyperthyroidism and subclinical hypothyroidism, which contributed to the early discovery of subclinical hyperthyroidism.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism
    AU  - Li Hongyan
    AU  - Zhang Chunhui
    AU  - Wang Hongsheng
    AU  - Xu Qian
    Y1  - 2019/09/27
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sjph.20190705.14
    DO  - 10.11648/j.sjph.20190705.14
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 159
    EP  - 162
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20190705.14
    AB  - Objective: This paper is to explore the relationship between IL-2, IL-6, IL-8 and the development of hyperthyroidism and subclinical hyperthyroidism. Methods The serum levels of IL-2, IL-6 and IL-8 were determined in 251 cases of hyperthyroidism, 242 cases of subclinical hyperthyroidism and 130 cases of normal control. Results The level of IL-2 in hyperthyroidism group was significantly lower than that in the control group (P<0.01), and the levels of IL-6 and IL-8 were significantly higher than those in the control group (P<0.01); The level of IL-2 in subclinical hyperthyroidism group was lower than that in the control group (P<0.05), and the levels of IL-6 and IL-8 were higher than those in the control group (P<0.05). The level of IL-2 in hyperthyroidism group was lower than that in subclinical hyperthyroidism group, and the level of IL-6 and IL-8 were higher than those in subclinical hyperthyroidism group. The two groups of IL-2 were negatively correlated with serum FT3, FT 4, TT3, and TT4, and IL-6 and IL-8 were positively correlated with serum FT3, FT 4, TT3, and TT4. Conclusions IL-2, IL-6, and IL-8 all participated in the development process of hyperthyroidism and subclinical hypothyroidism, which contributed to the early discovery of subclinical hyperthyroidism.
    VL  - 7
    IS  - 5
    ER  - 

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Author Information
  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Department of Blood Transfusion of Hejian People's Hospital, Cangzhou, China

  • Thyroid Diagnosis and Treatment Center of Cangzhou Traditional Chinese Medicine-Western Hospital, Cangzhou, China

  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Sections