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The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management

Received: 16 September 2018     Published: 18 September 2018
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Abstract

Discus the management of Enhanced recovery after surgery,levels and clinical meaning of interleukin IL-18 and IL-6 in peripheral blood of patients with sleep apnea hypopnea syndrome (OSAHS). By ELISA to detect the levels of IL-18 and IL-6 in serum and peripheral blood mononuclear cells (PBMCs) supernatants of OSAHS patients and healthy controls and check the changes in serum IL-18 and IL-6 levels in OSAHS patients before and after Han uvulopalatopharyngoplasty (H-UPPP) treatment. The levels of IL-18 and IL-6 in serum and PBMCs supernatant of OSAHS patients were higher than those of the matched group (P <0.05). The levels of serum IL-18 and IL-6 increased with the severity of OSAHS, and the levels of IL-18 and IL-6 in serum and PBMCs supernatants were positively correlated (P <0.05). After 2 months of H-UPPP, the serum levels of IL-18, IL-6 and the index of respiratory disturbance were significantly lower than before the treatment (P <0. 05). The sleep quality and nocturnal hypoxia were significantly improved, and the lowest oxygen saturation was significantly higher than before the treatment (P <0.05). IL-18 and IL-6 may play an important role in the pathogenesis and prognosis of OSAHS.

Published in Science Journal of Public Health (Volume 6, Issue 4)
DOI 10.11648/j.sjph.20180604.14
Page(s) 116-119
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

ERAS Management, Sleep Apnea, Hypoventilation Syndrome, IL-6, IL-18

References
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Cite This Article
  • APA Style

    Zejun Zhou, Fang Xu. (2018). The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management. Science Journal of Public Health, 6(4), 116-119. https://doi.org/10.11648/j.sjph.20180604.14

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    ACS Style

    Zejun Zhou; Fang Xu. The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management. Sci. J. Public Health 2018, 6(4), 116-119. doi: 10.11648/j.sjph.20180604.14

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    AMA Style

    Zejun Zhou, Fang Xu. The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management. Sci J Public Health. 2018;6(4):116-119. doi: 10.11648/j.sjph.20180604.14

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  • @article{10.11648/j.sjph.20180604.14,
      author = {Zejun Zhou and Fang Xu},
      title = {The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management},
      journal = {Science Journal of Public Health},
      volume = {6},
      number = {4},
      pages = {116-119},
      doi = {10.11648/j.sjph.20180604.14},
      url = {https://doi.org/10.11648/j.sjph.20180604.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20180604.14},
      abstract = {Discus the management of Enhanced recovery after surgery,levels and clinical meaning of interleukin IL-18 and IL-6 in peripheral blood of patients with sleep apnea hypopnea syndrome (OSAHS). By ELISA to detect the levels of IL-18 and IL-6 in serum and peripheral blood mononuclear cells (PBMCs) supernatants of OSAHS patients and healthy controls and check the changes in serum IL-18 and IL-6 levels in OSAHS patients before and after Han uvulopalatopharyngoplasty (H-UPPP) treatment. The levels of IL-18 and IL-6 in serum and PBMCs supernatant of OSAHS patients were higher than those of the matched group (P <0.05). The levels of serum IL-18 and IL-6 increased with the severity of OSAHS, and the levels of IL-18 and IL-6 in serum and PBMCs supernatants were positively correlated (P <0.05). After 2 months of H-UPPP, the serum levels of IL-18, IL-6 and the index of respiratory disturbance were significantly lower than before the treatment (P <0. 05). The sleep quality and nocturnal hypoxia were significantly improved, and the lowest oxygen saturation was significantly higher than before the treatment (P <0.05). IL-18 and IL-6 may play an important role in the pathogenesis and prognosis of OSAHS.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management
    AU  - Zejun Zhou
    AU  - Fang Xu
    Y1  - 2018/09/18
    PY  - 2018
    N1  - https://doi.org/10.11648/j.sjph.20180604.14
    DO  - 10.11648/j.sjph.20180604.14
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
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    EP  - 119
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20180604.14
    AB  - Discus the management of Enhanced recovery after surgery,levels and clinical meaning of interleukin IL-18 and IL-6 in peripheral blood of patients with sleep apnea hypopnea syndrome (OSAHS). By ELISA to detect the levels of IL-18 and IL-6 in serum and peripheral blood mononuclear cells (PBMCs) supernatants of OSAHS patients and healthy controls and check the changes in serum IL-18 and IL-6 levels in OSAHS patients before and after Han uvulopalatopharyngoplasty (H-UPPP) treatment. The levels of IL-18 and IL-6 in serum and PBMCs supernatant of OSAHS patients were higher than those of the matched group (P <0.05). The levels of serum IL-18 and IL-6 increased with the severity of OSAHS, and the levels of IL-18 and IL-6 in serum and PBMCs supernatants were positively correlated (P <0.05). After 2 months of H-UPPP, the serum levels of IL-18, IL-6 and the index of respiratory disturbance were significantly lower than before the treatment (P <0. 05). The sleep quality and nocturnal hypoxia were significantly improved, and the lowest oxygen saturation was significantly higher than before the treatment (P <0.05). IL-18 and IL-6 may play an important role in the pathogenesis and prognosis of OSAHS.
    VL  - 6
    IS  - 4
    ER  - 

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Author Information
  • Otolaryngology Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China

  • Medical Examination Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China

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