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Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine

Received: 6 March 2017     Published: 20 March 2017
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Abstract

In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.

Published in Science Journal of Public Health (Volume 5, Issue 3)
DOI 10.11648/j.sjph.20170503.17
Page(s) 198-204
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Thyroid Hormone, Thyroid Dysfunction, Thyroid Autoantibody, Health Examination

References
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    Hou Zhenjiang, Mu Zhaoxin, Wang Fengling, Li Hongyan, Zhang Jingyu, et al. (2017). Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Science Journal of Public Health, 5(3), 198-204. https://doi.org/10.11648/j.sjph.20170503.17

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    ACS Style

    Hou Zhenjiang; Mu Zhaoxin; Wang Fengling; Li Hongyan; Zhang Jingyu, et al. Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Sci. J. Public Health 2017, 5(3), 198-204. doi: 10.11648/j.sjph.20170503.17

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    AMA Style

    Hou Zhenjiang, Mu Zhaoxin, Wang Fengling, Li Hongyan, Zhang Jingyu, et al. Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Sci J Public Health. 2017;5(3):198-204. doi: 10.11648/j.sjph.20170503.17

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  • @article{10.11648/j.sjph.20170503.17,
      author = {Hou Zhenjiang and Mu Zhaoxin and Wang Fengling and Li Hongyan and Zhang Jingyu and Fan Hong and Wang Huaxin},
      title = {Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine},
      journal = {Science Journal of Public Health},
      volume = {5},
      number = {3},
      pages = {198-204},
      doi = {10.11648/j.sjph.20170503.17},
      url = {https://doi.org/10.11648/j.sjph.20170503.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20170503.17},
      abstract = {In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine
    AU  - Hou Zhenjiang
    AU  - Mu Zhaoxin
    AU  - Wang Fengling
    AU  - Li Hongyan
    AU  - Zhang Jingyu
    AU  - Fan Hong
    AU  - Wang Huaxin
    Y1  - 2017/03/20
    PY  - 2017
    N1  - https://doi.org/10.11648/j.sjph.20170503.17
    DO  - 10.11648/j.sjph.20170503.17
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 198
    EP  - 204
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20170503.17
    AB  - In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.
    VL  - 5
    IS  - 3
    ER  - 

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Author Information
  • Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China

  • Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China

  • Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China

  • Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China

  • Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

  • Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

  • Hebei Huanghua Development Zone Bo’ai Hospital, Huanghua, China

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