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Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies

Received: 3 February 2016     Accepted: 17 February 2016     Published: 1 March 2016
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Abstract

The relationship between statin use and the risk of hepatocellular carcinoma (HCC) remains controversial. Therefore, we conducted a meta-analysis to clarify this issue. Data on the relationship between statin use and the risk of HCC were collected through an electronic search of PubMed database. Summary odds ratios (ORs) with 95% confidential intervals were calculated using a random-effects model. Six studies were selected for the final meta-analysis, involving 3778 cases and 482452 patients. Our meta-analysis showed that statin use was significantly associated with a decreased risk of HCC (OR, 0.60, 95% confidence interval, 0.48–0.76). In conclusion, the meta-analysis suggests that statin use is associated with a reduced risk of HCC. However, our findings should be interpreted with caution due to limited studies.

Published in Science Journal of Public Health (Volume 4, Issue 2)
DOI 10.11648/j.sjph.20160402.11
Page(s) 81-87
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Statin, Hepatocellular Carcinoma, Meta-Analysis

References
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  • APA Style

    De-Sen Xiang, Jing Zhang. (2016). Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies. Science Journal of Public Health, 4(2), 81-87. https://doi.org/10.11648/j.sjph.20160402.11

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    ACS Style

    De-Sen Xiang; Jing Zhang. Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies. Sci. J. Public Health 2016, 4(2), 81-87. doi: 10.11648/j.sjph.20160402.11

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    AMA Style

    De-Sen Xiang, Jing Zhang. Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies. Sci J Public Health. 2016;4(2):81-87. doi: 10.11648/j.sjph.20160402.11

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  • @article{10.11648/j.sjph.20160402.11,
      author = {De-Sen Xiang and Jing Zhang},
      title = {Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies},
      journal = {Science Journal of Public Health},
      volume = {4},
      number = {2},
      pages = {81-87},
      doi = {10.11648/j.sjph.20160402.11},
      url = {https://doi.org/10.11648/j.sjph.20160402.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20160402.11},
      abstract = {The relationship between statin use and the risk of hepatocellular carcinoma (HCC) remains controversial. Therefore, we conducted a meta-analysis to clarify this issue. Data on the relationship between statin use and the risk of HCC were collected through an electronic search of PubMed database. Summary odds ratios (ORs) with 95% confidential intervals were calculated using a random-effects model. Six studies were selected for the final meta-analysis, involving 3778 cases and 482452 patients. Our meta-analysis showed that statin use was significantly associated with a decreased risk of HCC (OR, 0.60, 95% confidence interval, 0.48–0.76). In conclusion, the meta-analysis suggests that statin use is associated with a reduced risk of HCC. However, our findings should be interpreted with caution due to limited studies.},
     year = {2016}
    }
    

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    T1  - Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies
    AU  - De-Sen Xiang
    AU  - Jing Zhang
    Y1  - 2016/03/01
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    DO  - 10.11648/j.sjph.20160402.11
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
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    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20160402.11
    AB  - The relationship between statin use and the risk of hepatocellular carcinoma (HCC) remains controversial. Therefore, we conducted a meta-analysis to clarify this issue. Data on the relationship between statin use and the risk of HCC were collected through an electronic search of PubMed database. Summary odds ratios (ORs) with 95% confidential intervals were calculated using a random-effects model. Six studies were selected for the final meta-analysis, involving 3778 cases and 482452 patients. Our meta-analysis showed that statin use was significantly associated with a decreased risk of HCC (OR, 0.60, 95% confidence interval, 0.48–0.76). In conclusion, the meta-analysis suggests that statin use is associated with a reduced risk of HCC. However, our findings should be interpreted with caution due to limited studies.
    VL  - 4
    IS  - 2
    ER  - 

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Author Information
  • Department of General Surgery, Qianjiang Central Hospital of Chongqing Municipality, Chongqing, China

  • Department of General Surgery, Qianjiang Central Hospital of Chongqing Municipality, Chongqing, China

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